In a multi-year engagement, MUS conducted extensive usability, information foraging, and decision analysis of online content categories and presentation formats focused on defining information structures that had the greatest impact on clinical outcomes of cancer patients. Executed the complex analysis of the relationship between cancer information presentation frameworks and patient clinical outcomes based on the application of information foraging theory and task analysis. Identified key knowledge domains for cancer patients based on analysis of 2.5 million message board posts between cancer patients, doctors, and HCPs. Provided a robust view of the relationship between information presentation format and clinical outcomes. Utilized and optimized specialized semantic content software analysis methodology to capture and provide detailed insight into the massive data set of live message board posts. Researched successfully identified the relative and absolute effectiveness of communicating cancer information to patients via various mediums including doctor dialogue, printed documents, online research reports, government research reports, printed publications, and online live message boards. Findings provided profound and surprising insights into which forms of information presentation have the largest impact on clinical outcomes.